阮文科,博士,教授,动物医学系主任。中国农业大学博士研究生毕业。2003年进入红桃视频
工作。中国微生物学会兽医微生物专业委员会第一届青年学组委员;北京畜牧兽医学会小动物分会第四届理事。主讲动物免疫学和高级动物免疫学等课程,北京高等红桃视频
优秀专业课(公共课)主讲教师,入选北京市教委青年拔尖人才和市委组织部优秀人才项目。
研究领域为动物微生物学与免疫学。目前的主要研究方向为动物病毒蛋白与宿主蛋白的相互作用,以及免疫分子与病原之间的相互作用机理。主持完成国家自然科学基金面上项目、北京自然科学基金面上项目、北京市农委菜篮子项目、北京市科委创新券项目、北京市教委科研计划项目以及北京市科协金桥种子项目等。
代表性论文和专利:
1.Hao Dong, Yue Hao, Jue Wang, Shengkui Xu#,Wenke Ruan#.Japanese Encephalitis virus NS1 inhibits IFN-βproduction by interacting with DDX3X.Journal of Virology,May 2025 Volume 99 Issue 5, 10.1128/jvi.00077-25.Corresponding author
2.Hao Dong*, Xueyan Li*, Shengkui Xu, Yuxin Wang, Ting Xia, Peng Li,Wenke Ruan#.Proteomic analyses identify intracellular targets for avian coronavirus NSP10.Archives of Virology, 2025 Mar 13;170(4):74. doi: 10.1007/s00705-025-06255-z.Corresponding author
3、Ting xia, Shengkui xu, Xueyan li,Wenke ruan.Avian coronavirus infectious bronchitis virus Beaudette Strain NSP9 interacts with STAT1 and inhibits its phosphorylation to facilitate viral replication.Virology. 2024 Feb:590:109944.Corresponding author
4、Hao Dong , Shengkui Xu , Peng Li ,Wenke Ruan.The battle between infectious bronchitis virus and innate immunity: A mini review.Virology. 2024 Nov 29:603:110321. doi: 10.1016/j.virol.2024.110321. Corresponding author
5、Shengkui Xu, Bowen Zhang, Jielin Yao,Wenke Ruan.A new H9 influenza virus mRNA vaccine elicits robust protectiveimmunity against infection.Vaccine, Volume 41, Issue 18, 2 May 2023, Pages 2905-2913.Corresponding author
6、Li X, Li Q,Ruan W.Identification of Avian Toll-Like Receptor 3 and7 and Analysis of Gene Variation Sites.Brazilian Journal of Poultry Science.2022, 24(3).
7、Peng Wang, Xinze Liu, Qi Li, Jue Wang,Wenke Ruan. Proteomic analyses identify intracellular targets for Japanese encephalitis virus nonstructural protein 1 (NS1).Virus Res, 2021 Jun 24;302:198495. doi: 10.1016/j.virusres.2021.198495. Corresponding author
8、Jinyan Zhu, Shuang Xu, Xueyan Li, Jue Wang, Yueqi Jiang, Weichen Hu,Wenke Ruan,Infectious Bronchitis Virus Inhibits Activation of the TLR7 Pathway, but Not the TLR3 Pathway.Arch Virol, 2020 Jun 10;1-7.doi:10.1007/s00705-020-04690-8. Corresponding author
9、Peng Wang, Jinyan Zhu, Xinze Liu, Jiaojiao Guo, Xuejia Gu,Wenke Ruan.Isolation and recombinant analysis of variants of porcine epidemic diarrhea virus strains from Beijing, China.VirusDis. DOI 10.1007/s13337-019-00513-w1, 2019. Corresponding author
10、WenkeRuan,Jian An,YanhuaWu, Polymorphisms of chicken TLR3 and 7 in different breeds,PLoS ONE2015.10(3): e0119967. doi:10.1371/journal. pone.0119967. Corresponding author
11、JJ Zhang, LX Wang,WK Ruan, J An.Investigation into the prevalence of coccidiosis and maduramycin drug resistance in chickens in China.Veterinary Parasitology,2013 Jan 16;191(1-2):29-34.co-First Author
12、WKRuan, YHWu, J An, SJZheng.Polymorphisms of chicken Toll-like receptors 4, 15, and 21 in different breeds.Poultry Science, 91, 2512-2516, 2012. Corresponding author
13、Yanhua Wu,WenkeRuan, Defeng Cui, Huanrong li.Identification of a toll-like receptor1 in guinea fowl (Agelastesniger).Biochemical genetics, 50, 702–716, 2012. Corresponding author
14、WKRuan, YHWu, J An, DFCui, HRLi,SJZheng.Toll-like receptor 2 type 1 and type 2 polymorphisms in different chicken breeds.Poultry Science, 91, 101-106. 2012. First Author.
15、WenkeRuan, Yanhua Wu, ShijunZheng.Different genetic patterns in avian Toll-like receptor (TLR)5 genes.Molecular Biology Reports, 39, 3419-3426, 2012, First Author.
16、WKRuanandSJZheng.Polymorphisms of chicken toll-like receptor 1 type 1 and type 2 in different breeds.Poultry Science, 90, 1941-1947, 2011. First Author.
17、董昊,徐胜奎,郝悦,阮文科.乙型脑炎病毒激活天然免疫应答的特点.中国兽医杂志2024,60( 9) : 84-91.通讯作者
18、李雪妍,徐双,朱瑾彦,阮文科.禽冠状病毒组织嗜性和固有免疫应答差异研究.病毒学报,2021,37(03),658-666.通讯作者
19、国家发明专利:阮文科,郭娇娇,阮莹钰,张建军,谷学佳、徐双,用于检测PEDV变异株抗体的抗原及方法和试剂盒,2016.7.13中国,ZL 2016 1 0552724.6
20、国家发明专利:阮文科,郭娇娇,王真,吴艳花,崔德凤,小片段gG抗原及其在检测伪狂犬病毒gG抗体中的应用,2015.9.15,中国,ZL 2015 1 0587831.8
获奖情况:
1、北京高等红桃视频
优秀专业课(公共课)主讲教师(2023)
2、动物免疫学-北京高等红桃视频
优质本科课程(2023)
3、动物免疫学-北京高等红桃视频
优质本科教案(2023)
4、带头人,红桃视频
兽药与疫病防控教学团队,北京市高校继续教育高水平教学团队(2019)
5、排名第一,红桃视频
第二届研究生教育教学成果二等奖(2020)
6、排名第三,红桃视频
第一届研究生教育教学成果二等奖(2017)
7、红桃视频
优秀共产党员
8、红桃视频
就业工作突出贡献导师(2016)
9、红桃视频
招生工作突出贡献导师(2019)
10、红桃视频
三育人先进工作者(2010-2012)
11、导师,北京高校优秀毕业生(2022)